{"id":63,"date":"2017-02-08T13:03:37","date_gmt":"2017-02-08T13:03:37","guid":{"rendered":"http:\/\/server.paap.cup.edu.uy\/wordpress_hlab\/?p=63"},"modified":"2017-07-04T13:34:17","modified_gmt":"2017-07-04T13:34:17","slug":"estructura-3d-de-una-proteina","status":"publish","type":"post","link":"https:\/\/hlab.cup.edu.uy\/index.php\/2017\/02\/08\/estructura-3d-de-una-proteina\/","title":{"rendered":"Obtenci\u00f3n de la estructura 3d de una prote\u00edna"},"content":{"rendered":"<p><strong>\u00bfQu\u00e9\u00a0 quisimos hacer?<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-364 alignleft\" src=\"http:\/\/server.paap.cup.edu.uy\/wordpress_hlab\/wp-content\/uploads\/2017\/02\/img1-300x240.png\" alt=\"img1\" width=\"300\" height=\"240\" srcset=\"https:\/\/hlab.cup.edu.uy\/wp-content\/uploads\/2017\/02\/img1-300x240.png 300w, https:\/\/hlab.cup.edu.uy\/wp-content\/uploads\/2017\/02\/img1.png 489w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<ul>\n<li>Obtener un modelo de la estructura proteica en 3D con fines did\u00e1cticos.<\/li>\n<li>Poner a punto un protocolo de impresi\u00f3n que fuera capaz de reproducir la complejidad de la estructura.<\/li>\n<li>Aprender sobre el dise\u00f1o 3D y c\u00f3mo usar la impresora 3D.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<hr \/>\n<p><strong>\u00bfC\u00f3mo lo hicimos?<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-371 alignleft\" src=\"http:\/\/server.paap.cup.edu.uy\/wordpress_hlab\/wp-content\/uploads\/2017\/02\/1.png\" alt=\"1\" width=\"37\" height=\"50\" \/><br \/>\nUna vez identificada la prote\u00edna fue necesario recurrir a un <strong>modelo 3D<\/strong> de la misma<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-365 alignleft\" src=\"http:\/\/server.paap.cup.edu.uy\/wordpress_hlab\/wp-content\/uploads\/2017\/02\/img2-300x128.png\" alt=\"img2\" width=\"300\" height=\"128\" srcset=\"https:\/\/hlab.cup.edu.uy\/wp-content\/uploads\/2017\/02\/img2-300x128.png 300w, https:\/\/hlab.cup.edu.uy\/wp-content\/uploads\/2017\/02\/img2.png 518w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/><\/p>\n<ul>\n<li>Muchas prote\u00ednas cuentan con archivos que proporcionan coordenadas para obtener modelos (archivos STL).<\/li>\n<li>La otra opci\u00f3n era recurrir a una prote\u00edna que ya contara con un modelo en 3D en la web.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-373 alignleft\" src=\"http:\/\/server.paap.cup.edu.uy\/wordpress_hlab\/wp-content\/uploads\/2017\/02\/2.png\" alt=\"2\" width=\"40\" height=\"50\" \/><br \/>\nElecci\u00f3n de la prote\u00edna a imprimir<\/p>\n<div class=\"su-row\"><div class=\"su-column su-column-size-1-1\"><div class=\"su-column-inner su-u-clearfix su-u-trim\">\n<p>Decidimos imprimir una prote\u00edna que es secretada por un par\u00e1sito de inter\u00e9s para la actividad ganadera de nuestro pa\u00eds: <span style=\"color: #0000ff;\"><i>Fasciola <\/i><i>hepatica<\/i><\/span><\/p>\n<p>Las razones:<\/p>\n<ul>\n<li>Es una prote\u00edna de la que ten\u00edamos un modelo adecuado para generar el archivo 3D.<\/li>\n<li>Posee tanto hojas plegadas Beta y h\u00e9lices alfa en su estructura secundaria. Lo que servir\u00e1 para explicar a los estudiantes.<\/li>\n<\/ul>\n<\/div><\/div> <\/div>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-374 alignnone\" src=\"http:\/\/server.paap.cup.edu.uy\/wordpress_hlab\/wp-content\/uploads\/2017\/02\/3.png\" alt=\"3\" width=\"40\" height=\"50\" \/><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-366 alignleft\" src=\"http:\/\/server.paap.cup.edu.uy\/wordpress_hlab\/wp-content\/uploads\/2017\/02\/img3-179x300.png\" alt=\"img3\" width=\"179\" height=\"300\" srcset=\"https:\/\/hlab.cup.edu.uy\/wp-content\/uploads\/2017\/02\/img3-179x300.png 179w, https:\/\/hlab.cup.edu.uy\/wp-content\/uploads\/2017\/02\/img3.png 371w\" sizes=\"auto, (max-width: 179px) 100vw, 179px\" \/><br \/>\nPrimera prueba de impresi\u00f3n a mini-escala<\/p>\n<p>La prueba dio una noci\u00f3n de la dificultad del asunto y proporcion\u00f3 una idea clara de c\u00f3mo orientar la prote\u00edna para la impresi\u00f3n.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-367 alignleft\" src=\"http:\/\/server.paap.cup.edu.uy\/wordpress_hlab\/wp-content\/uploads\/2017\/02\/img4-179x300.png\" alt=\"img4\" width=\"179\" height=\"300\" srcset=\"https:\/\/hlab.cup.edu.uy\/wp-content\/uploads\/2017\/02\/img4-179x300.png 179w, https:\/\/hlab.cup.edu.uy\/wp-content\/uploads\/2017\/02\/img4.png 371w\" sizes=\"auto, (max-width: 179px) 100vw, 179px\" \/>Resultados del Primer intento<\/p>\n<p>\u00bfQu\u00e9 sucedi\u00f3?<\/p>\n<ul>\n<li>Faltaron apoyos y soportes.<\/li>\n<li>Los primeros 15 minutos funcion\u00f3 porque las capas a\u00fan ten\u00edan apoyo.<\/li>\n<li>Se cort\u00f3 la impresi\u00f3n en el momento que se advirti\u00f3 el problema.<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<hr \/>\n<p><strong>El Modelo y sus problemas<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-medium wp-image-368 alignleft\" src=\"http:\/\/server.paap.cup.edu.uy\/wordpress_hlab\/wp-content\/uploads\/2017\/02\/img5-300x216.png\" alt=\"img5\" width=\"300\" height=\"216\" srcset=\"https:\/\/hlab.cup.edu.uy\/wp-content\/uploads\/2017\/02\/img5-300x216.png 300w, https:\/\/hlab.cup.edu.uy\/wp-content\/uploads\/2017\/02\/img5.png 607w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/>Si bien cont\u00e1bamos con el pdb, tuvimos que generar a partir \u00e9ste el archivo STL. Esto se logr\u00f3 mediante el programa VMD.<\/p>\n<p>Es una estructura compleja con muchos espacios en blanco y loops que son fr\u00e1giles.<\/p>\n<p>Se requieren soportes suficientes para solucionar problemas de estabilidad y puntos de apoyo para la impresi\u00f3n.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-375 alignleft\" src=\"http:\/\/server.paap.cup.edu.uy\/wordpress_hlab\/wp-content\/uploads\/2017\/02\/4.png\" alt=\"4\" width=\"40\" height=\"50\" \/><br \/>\n<strong>Soluci\u00f3n a los problemas detectados: Generando el archivo para la impresi\u00f3n final<\/strong><\/p>\n<ul>\n<li>Se coloc\u00f3 a la prote\u00edna para intentar aumentar los puntos de contacto con la superficie de impresi\u00f3n.<\/li>\n<li>Se colocaron soportes y puntos de apoyo necesarios para la impresi\u00f3n.<\/li>\n<\/ul>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-369 size-full\" src=\"http:\/\/server.paap.cup.edu.uy\/wordpress_hlab\/wp-content\/uploads\/2017\/02\/img6.png\" alt=\"img6\" width=\"1283\" height=\"677\" srcset=\"https:\/\/hlab.cup.edu.uy\/wp-content\/uploads\/2017\/02\/img6.png 1283w, https:\/\/hlab.cup.edu.uy\/wp-content\/uploads\/2017\/02\/img6-300x158.png 300w, https:\/\/hlab.cup.edu.uy\/wp-content\/uploads\/2017\/02\/img6-768x405.png 768w, https:\/\/hlab.cup.edu.uy\/wp-content\/uploads\/2017\/02\/img6-1024x540.png 1024w\" sizes=\"auto, (max-width: 1283px) 100vw, 1283px\" \/><\/p>\n<hr \/>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"wp-image-376 alignleft\" src=\"http:\/\/server.paap.cup.edu.uy\/wordpress_hlab\/wp-content\/uploads\/2017\/02\/5.png\" alt=\"5\" width=\"39\" height=\"50\" \/><br \/>\n<strong>Imprimimos<\/strong><\/p>\n<hr \/>\n<p><strong>\u00bfCual fue el resultado?<\/strong><br \/>\nEl modelo terminado<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-370 size-full\" src=\"http:\/\/server.paap.cup.edu.uy\/wordpress_hlab\/wp-content\/uploads\/2017\/02\/img7.png\" alt=\"img7\" width=\"1050\" height=\"669\" srcset=\"https:\/\/hlab.cup.edu.uy\/wp-content\/uploads\/2017\/02\/img7.png 1050w, https:\/\/hlab.cup.edu.uy\/wp-content\/uploads\/2017\/02\/img7-300x191.png 300w, https:\/\/hlab.cup.edu.uy\/wp-content\/uploads\/2017\/02\/img7-768x489.png 768w, https:\/\/hlab.cup.edu.uy\/wp-content\/uploads\/2017\/02\/img7-1024x652.png 1024w\" sizes=\"auto, (max-width: 1050px) 100vw, 1050px\" \/><\/p>\n<p><span style=\"border-radius: 2px; text-indent: 20px; width: auto; padding: 0px 4px 0px 0px; text-align: center; font: bold 11px\/20px 'Helvetica Neue',Helvetica,sans-serif; color: #ffffff; background: #bd081c no-repeat scroll 3px 50% \/ 14px 14px; position: absolute; opacity: 1; z-index: 8675309; display: none; cursor: pointer;\">Guardar<\/span><\/p>\n<p><span style=\"border-radius: 2px; text-indent: 20px; width: auto; padding: 0px 4px 0px 0px; text-align: center; font: bold 11px\/20px 'Helvetica Neue',Helvetica,sans-serif; color: #ffffff; background: #bd081c no-repeat scroll 3px 50% \/ 14px 14px; position: absolute; opacity: 1; z-index: 8675309; display: none; cursor: pointer;\">Guardar<\/span><\/p>\n<p><span style=\"border-radius: 2px; text-indent: 20px; width: auto; padding: 0px 4px 0px 0px; text-align: center; font: bold 11px\/20px 'Helvetica Neue',Helvetica,sans-serif; color: #ffffff; background: #bd081c  no-repeat scroll 3px 50% \/ 14px 14px; position: absolute; opacity: 1; z-index: 8675309; display: none; cursor: pointer;\">Guardar<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":120,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[17,19,3],"tags":[],"class_list":["post-63","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-florencia-f","category-impresion-3d","category-proyectos"],"_links":{"self":[{"href":"https:\/\/hlab.cup.edu.uy\/index.php\/wp-json\/wp\/v2\/posts\/63","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hlab.cup.edu.uy\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/hlab.cup.edu.uy\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/hlab.cup.edu.uy\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/hlab.cup.edu.uy\/index.php\/wp-json\/wp\/v2\/comments?post=63"}],"version-history":[{"count":22,"href":"https:\/\/hlab.cup.edu.uy\/index.php\/wp-json\/wp\/v2\/posts\/63\/revisions"}],"predecessor-version":[{"id":666,"href":"https:\/\/hlab.cup.edu.uy\/index.php\/wp-json\/wp\/v2\/posts\/63\/revisions\/666"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/hlab.cup.edu.uy\/index.php\/wp-json\/wp\/v2\/media\/120"}],"wp:attachment":[{"href":"https:\/\/hlab.cup.edu.uy\/index.php\/wp-json\/wp\/v2\/media?parent=63"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/hlab.cup.edu.uy\/index.php\/wp-json\/wp\/v2\/categories?post=63"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/hlab.cup.edu.uy\/index.php\/wp-json\/wp\/v2\/tags?post=63"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}